第四章单元测试
  1. Which of the following DNA damages belongs to exogenous DNA damage ( ).

  2. A:Instability of DNA structure B:Inaccuracy in DNA replication C:Endogenous Oxidative DNA damage D:Ionizing radiation
    答案:Ionizing radiation
  3. Which type of DNA point mutations will not lead to the change in amino acid ( ).

  4. A:Missense mutation B:Nonsense mutation C:None of them D:Silent mutation
  5. which base substitution below belongs to “Transition” point mutation.( )

  6. A:C→T B:A→C C:A→T D:G→T
  7. Which is wrong below as described for directly undoing DNA damages repair.( )

  8. A:There is no any DNA synthesis B:Pyrimidine dimer caused by UV can be repaired by directly undoing DNA damage repair process in human cells. C:O6-methylguanine methyltransferase can directly remove O6 alkylations on guanine residues by directly undoing DNA damage repair. D:Converting altered nucleotide back to original form.
  9. In which process GG-NER and TC-NER show different( )

  10. A:DNA strand unwinding B:Nucleotides resynthesis C:DNA Strand excision D:DNA lesion recognition
  11. The deficiency of NER repair proteins is susceptible to_ disease.( )

  12. A:Sickle HbC B:Lynch syndrome C:Chronic myelogenous leukemia D:Xeroderma pigmentosum
  13. During mismatch repair in prokaryotes, the newly synthesized DNA is recognized by the lack of ( ) modification( )

  14. A:Deamination B:Methylation C:Acetylation D:Phosphorylation
  15. During double stranded DNA break repair, NHEJ shows more precise compared to HR. ( )

  16. A:错 B:对
  17. DNA damage is the main cause for the increased frequency of gene mutation. ( )

  18. A:错 B:对
  19. Base excision repair is one of DNA repair pathways to corrects large base lesions .( )

  20. A:错 B:对

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