- Which protein level will obviously decrease because of the liver damage?（ ）
- All of the following are true for both DNA polymerase and RNA polymerase EXCEPT （ ）.
- The bases of RNA are the same as those of DNA with the exception that RNA contains （ ） .
- The most important key enzyme in glycolysis is （ ）.
- Which of the following sequences is complementary to the DNA sequence 5'-AAGTCCGA-3'? （ ）
- Which of the following amino acid residues can be phosphorylated? （ ）
- Substrate level phosphorylation occurs in which of the following reactions? （ ）
- The chemiosmotic hypothesis for oxidative phosphorylation proposes that the driving force for the formation of ATP is （ ）
- The coenzyme of ALA synthase is the active form of（ ）
- In RNA polymerase of E. coli, the subunit which can recognize the origin of transcription is （ ）.
- Which of the following statements most closely describes the phenomenon of uncoupling in oxidative phosphorylation? （ ）
- All of the following enzymes are linked to the reduction of NADH EXCEPT （ ）.
- Which bile pigment can easily go through the biomembrane?（ ）
- What is the enzyme catalyzed 2,3-BPG to form 2,3-BPG?（ ）
- FMN is the active form of （ ）.
- What is the main transportation form of bilirubin in serum?（ ）
- Post-translational modifications of polypeptides include all the following EXCEPT （ ）.
- Which statement about the Cori cycle is TRUE? （ ）
- All of the following statements about DNA replication in prokaryotes are true EXCEPT which one?（ ）
- Which of the following vitamin deficiencies can cause beriberi? （ ）
- If the base sequence in a fragment of the coding strand of DNA is 5′-ACTACTCAG-3′, corresponding sequence of mRNA produced by transcription is （ ）.
- When [S]=4 Km, the velocity of the enzymatic reaction is about （ ）.
- Which following can feedback inhibit ALA synthase?（ ）
- Export of acetyl-CoA from mitochondria to cytosol to participate in fatty acid or steroid biosynthesis involves （ ）
- The arrangement of atoms on the backbone of the polypeptide chain can be expressed as （ ）.
- The maximal absorption peak of nucleic acid to UV light is at （ ）
- The effect of competitive inhibitor on enzyme-catalyzed velocity is （ ）.
- Which of the following can results in the frameshift mutation of DNA? （ ）
- During eukaryotic DNA replication, the enzyme that catalyze the synthesis of lagging strand is （ ）
- In the electron transport scheme below, which electron carrier is missing? （ ）NADH FMNH2 ? cytochromes O2
- Promoter is defined as （ ）
- The most common donor of methyl groups in biosynthetic reactions is （ ）
- The phenomenon which a single amino acid is coded for by several different triplet codons is called （ ） of genetic codons.
- ATP is directly required in protein biosynthesis for （ ）.
- Which of the following state is positive nitrogen balance? （ ）
- Which type of the following histones is not a component in the core particles of the nucleosome? （ ）
- .Which group of amino acids has only one genetic coden correspondingly? （ ）
- The direct precursor of dTMP synthesis is（ ）.
- Which one of the following enzymes deficiency can lead to Lesch-Nyhan syndrome?（ ）
- The most important chemical bond that maintain a protein's primary structure is （ ）.
- Okazaki fragments are （ ）
- Which one of the following is true about denatured proteins? （ ）
- Gluconeogenesis takes place predominantly in （ ）.
- All of the following statements about allosteric enzymes are true EXCEPT （ ）.
- Which of the following is not the direct material of de novo synthesis of purine nucleotide?（ ）.
- Which one of the following statements is wrong? （ ）
- The type of nucleic acid that usually contains small quantities of a variety of modified ribonucleotides, such as pseudouridine and inosine, is （ ）.
- What is the fecal color of the patients with obstructive jaundice?（ ）
- The cause of the bilirubin in the urine is（ ）
- Xeroderma pigmentosum results from a deficiency in（ ）
- The direction of protein synthesis (polypeptide chain) is （ ）
- The concept of "wobble" involves_____. （ ）
- Which of the following steps is NOT included in the protein biosynthesis? （ ）
- The gene expression can be regulated at the following levels EXCEPT （ ）
- The mRNA sequence: (5’) AAUGCAGCUUUAGCA (3’) and the sequence of the coding strand is____. （ ）
- If the coden of mRNA is ACG, then the anticoden of tRNA is （ ）
- The sequence of nucleotide of initiation coden is （ ）
- Peptidyl transferase_____. （ ）
- RNA polymerase is bound initially to _____ of an operon? （ ）
- Post-translational modifications of polypeptides include all the following EXCEPT _____? （ ）
- The AAUAAA sequence on a RNA molecule marks_____. （ ）
- The TATA box in eukaryotes is a_____. （ ）
- Indicate which of the following events can occur during the processing of eukaryotic mRNA transcripts. （ ）
- Which of the following is NOT true of the prokaryotic (E. coli) transcriptional process? （ ）
- Which of the following statements is correct about prokaryotic gene expression? （ ）
- The template strand of DNA is 5’-ATTCAG-3 ’ , its transcript is （ ）
- Regarding the process of DNA replication in E. coli which of the following statements is WRONG? （ ）
- The enzyme in charge of proofreading function in DNA replication is （ ）
- All of the following statements concerning DNA replication in prokaryotes are true EXCEPT ____? （ ）
- Xeroderma pigmentosum (xp) results from a deficiency in_____. （ ）
- What is the function of the 3' to 5' exonuclease activity of bacterial DNA polymerases? （ ）
- The sequence of one DNA strand is ATGCAA, the complementary strand of DNA is （ ）
- In the replication of eukaryotic DNA, （ ）
- Okazaki fragments are _____. （ ）
- DNA polymerase I do not has_____. （ ）
- DNA polymerase III can only add nucleotides to an existing chain, so _____ is required. （ ）
- What‘s the materials of heme synthesis? （ ）
- What do the daily bilirubin formation derive mainly from? （ ）
- How many oxygens can a molecule of hemoglobin bind? （ ）
- Unconjugated bilirubin can be secreted into the urine in our bodies. （ ）
- The bilirubin is sparingly soluble in plasma and water. （ ）
- In the enterohepatic circulation only a little fraction of bile acids are reabsorbed in the intestine. （ ）
- Which of the following enzyme is the rate-limiting enzyme in the process of bile acids synthesis? （ ）
- Which of the following reactions is the most common conjugation in the liver? （ ）
- All products of liver biotransformation are nontoxic. （ ）
- The principal nitrogenous urinary excretion product in humans resulting from the catabolism of AMP is（ ）
- Which of the following is not a physiological role of nucleotide?（ ）。
- Which one of the following does not occurs in the degradation pathway of AMP?（ ）
- Which of the following substance directly links nucleotide synthesis and glucose metabolism?（ ）。
- Which of the following is the common material for the synthesis of pyrimidine and purine nucleotide?（ ）。
- The primary function of the urea cycle is （ ）
- The amino acid that is involved in almost every aminotransferase reaction is （ ）
- All of the following are essential amino acids EXCEPT （ ）
- Pyridoxal phosphate acts as coenzyme in most （ ）
- The nitrogens in urea originate MOST DIRECTLY (fewest number of steps) from （ ）
- ATP synthase carry out substrate level phosphorylations . （ ）
- The uncoupling of oxidative phosphorylation found in the brown fat mitochondria of a newborn infant might be of physiological importance because （ ）
- Which of the following components of the mitochondrial electron transport system are incapable of carrying 2 electrons? （ ）
- The mitochondrial electron transport system responsible for reoxidation of NADH and electron transfer to oxygen is located in inner membrane of the mitochondria.（ ）
- The main function of the glycerol phosphate shuttle is in （ ）
- Which of the following is an intermediate in ketone body synthesis? （ ）
- Which of the following enzymes catalyzes the rate controlling step in fatty acid biosynthesis?（ ）
- Fatty acids from adipose tissue are transported to sites of utilization in the form of （ ）
- HMGCoA can act as a precursor for all of the following EXCEPT:（ ）
- Indicate the correct sequence of reactions employed for beta-oxidation of acyl-CoA derivatives from the list below. （ ）
- Which coenzyme in pyruvate dehydrogenase complex serves as the final hydrogens acceptor? （ ）
- The direct donor of glucosyl group in glycogenesis is （ ）.
- Which pathway of the following is related to nucleic acids synthesis? （ ）
- Which of the following hormones can lower blood glucose？ （ ）
- Muscle glycogen cannot replenish blood sugar because muscle cells lack （ ）
- Which of the following vitamins contains the metal cobalt atom？（ ）
- Folate deficiency can cause （ ）
- The active form of vitamin D in the body is （ ）
- Which of the following vitamin deficiencies causes night blindness? （ ）
- Which of following vitamins can be converted into NAD+ and NADP+? （ ）
- Analog of sulfonamide is （ ）
- If the enzymatic velocity is 90% of Vmax, [S] should be （ ） times of Km.
- The effect of non-competitive inhibitor on enzyme-catalyzed velocity is （ ）
- The specificity of enzyme is determined by （ ）
- The physiological significance of zymogen activation is （ ）
- The codon in mRNA reversely complementary pairing with anti-codon UGC in tRNA is （ ）
- Which of the following statements about nucleosome structure is correct? （ ）
- The base is found in mRNA but not in DNA is （ ）
- If the content of adenine is 15% in a DNA double helix, that of cytosine is （ ）
- The 5′end of mRNA in most eukaryotes has （ ）
- The amino acid which does not exist in natural proteins is （ ）
- Which set of amino acids can absorb 280 nm UV light? （ ）
- Essential of protein denaturation is （ ）
- The formation of protein secondary structure is mainly dependent on（ ）
- Which of the following amino acids is involved in the formation of disulfide bridge?（ ）
答案:Albumin
答案:both require a primer
答案:uracil instead of thymine
答案:phosphofructokinase-1
答案:3'-TTCAGGCT-5'
答案:Ser
答案:Succinyl-CoA→ succinate
答案:a proton gradient across the mitochondrial membrane
答案:Vit B6
答案:σ subunit
答案:ATP formation ceases, but oxygen consumption continues
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